Trombosis aórtica en una mujer con arteritis de Takayasu, ¿manifestación inusual o compromiso paraneoplásico? Reporte de caso
Palabras clave:
arteritis de Takayasu, vasculitis sistémica, trombosis, neoplasias mamarias, anticoagulantes, inmunosupresores
Resumen
La arteritis de Takayasu es una vasculitis de grandes vasos que afecta la aorta y sus principales ramas, caracterizada por síntomas sistémicos inespecíficos y anomalías vasculares, principalmente estenosis o enfermedad aneurismática. La arteritis de Takayasu carece de una asociación clara con eventos trombóticos. El vínculo poco frecuente entre cáncer y vasculitis destaca la necesidad de una evaluación exhaustiva de los trastornos procoagulantes en pacientes con arteritis de Takayasu y trombosis. Presentamos un caso único de trombosis como manifestación inicial de arteritis de Takayasu.Citas
I. Numano F. The story of Takayasu arteritis. Rheumatology (Oxford). 2002;41(1):103-106. doi: 10.1093/rheumatology/41.1.103.
II. Mason JC. Takayasu arteritis-advances in diagnosis and management. Nat Rev Rheumatol. 2010;6(7):406-415. doi: 10.1038/nrrheum.2010.82.
III. JCS Joint Working Group. Guideline for management of vasculitis syndrome (JCS 2008). Japanese Circulation Society. Circ J. 2011;75(2):474-503. doi: 10.1253/circj.cj-88-0007.
IV. Maffei S, Di Renzo M, Bova G, et al. Takayasu’s arteritis: a review of the literature. Intern Emerg Med. 2006;1(2):105-112. doi: 10.1007/BF02936534.
V. Springer J, Villa-Forte A. Thrombosis in vasculitis. Curr Opin Rheumatol. 2013;25(1):19-25. doi: 10.1097/BOR.0b013e32835ad3ca.
VI. Azar L, Khasnis A. Paraneoplastic rheumatologic syndromes. Curr Opin Rheumatol. 2013;25(1):44-49. doi: 10.1097/BOR.0b013e328359e780.
VII. Fain O, Hamidou M, Cacoub P, et al. Vasculitides associated with malignancies: analysis of sixty patients. Arthritis Rheum. 2007;57(8):1473-1480. doi: 10.1002/art.23085.
VIII. Abdulla MC. Paraneoplastic small vessel vasculitis and Takayasu arteritis associated with polycythemia rubra vera. Int J Rheum Dis. 2020;23(7):986-988. doi: 10.1111/1756-185X.13882.
IX. Igawa T, Nakanishi M, Iwata S, et al. Hypercoagulable state in patients with Takayasu’s arteritis. Thromb Haemost. 1996;75(5):712-6.
X. Okada K, Nakazato Y, Nakamura M, et al. Unique case of Takayasu Arteritis with severe distal aortic stenosis and iliac thrombosis. Ann Vasc Surg. 2016;32:128.e7-13.
XI. Zykova SN, Shmeleva IY, Ivanova M, et al. Associations of F2 (G20210A), F5 (G1691A), F7 (G10976A), F13 (G13T), FGB, ITGA2, ITGB3, and PAI-I gene polymorphisms with cardiovascular and thrombotic complications in patients with Takayasu arteritis from the Urals population. Turk Kardiyol Dern Ars. 2021;49(6):448-455.
XII. Weitz JI, Lensing AW, Prins MH, et al. Late diagnosis of Takayasu’s arteritis with repeated attacks of heart failure and uncontrolled hypertension due to abdominal aortic thrombosis: case report and review of the literature. Blood Pressure. 2015;24:333-9.
13. Sari I, Demir M, Yilmaz E, et al. Antiplatelet therapy for the prevention of arterial ischemic events in Takayasu arteritis. Circ J. 2010;74(6):1236-41. doi: 10.1253/circj.CJ-09-0906.
II. Mason JC. Takayasu arteritis-advances in diagnosis and management. Nat Rev Rheumatol. 2010;6(7):406-415. doi: 10.1038/nrrheum.2010.82.
III. JCS Joint Working Group. Guideline for management of vasculitis syndrome (JCS 2008). Japanese Circulation Society. Circ J. 2011;75(2):474-503. doi: 10.1253/circj.cj-88-0007.
IV. Maffei S, Di Renzo M, Bova G, et al. Takayasu’s arteritis: a review of the literature. Intern Emerg Med. 2006;1(2):105-112. doi: 10.1007/BF02936534.
V. Springer J, Villa-Forte A. Thrombosis in vasculitis. Curr Opin Rheumatol. 2013;25(1):19-25. doi: 10.1097/BOR.0b013e32835ad3ca.
VI. Azar L, Khasnis A. Paraneoplastic rheumatologic syndromes. Curr Opin Rheumatol. 2013;25(1):44-49. doi: 10.1097/BOR.0b013e328359e780.
VII. Fain O, Hamidou M, Cacoub P, et al. Vasculitides associated with malignancies: analysis of sixty patients. Arthritis Rheum. 2007;57(8):1473-1480. doi: 10.1002/art.23085.
VIII. Abdulla MC. Paraneoplastic small vessel vasculitis and Takayasu arteritis associated with polycythemia rubra vera. Int J Rheum Dis. 2020;23(7):986-988. doi: 10.1111/1756-185X.13882.
IX. Igawa T, Nakanishi M, Iwata S, et al. Hypercoagulable state in patients with Takayasu’s arteritis. Thromb Haemost. 1996;75(5):712-6.
X. Okada K, Nakazato Y, Nakamura M, et al. Unique case of Takayasu Arteritis with severe distal aortic stenosis and iliac thrombosis. Ann Vasc Surg. 2016;32:128.e7-13.
XI. Zykova SN, Shmeleva IY, Ivanova M, et al. Associations of F2 (G20210A), F5 (G1691A), F7 (G10976A), F13 (G13T), FGB, ITGA2, ITGB3, and PAI-I gene polymorphisms with cardiovascular and thrombotic complications in patients with Takayasu arteritis from the Urals population. Turk Kardiyol Dern Ars. 2021;49(6):448-455.
XII. Weitz JI, Lensing AW, Prins MH, et al. Late diagnosis of Takayasu’s arteritis with repeated attacks of heart failure and uncontrolled hypertension due to abdominal aortic thrombosis: case report and review of the literature. Blood Pressure. 2015;24:333-9.
13. Sari I, Demir M, Yilmaz E, et al. Antiplatelet therapy for the prevention of arterial ischemic events in Takayasu arteritis. Circ J. 2010;74(6):1236-41. doi: 10.1253/circj.CJ-09-0906.
Publicado
2025-09-22
Cómo citar
1.
Arango A, Giraldo L, Puerta J, Giraldo C, Cataño J. Trombosis aórtica en una mujer con arteritis de Takayasu, ¿manifestación inusual o compromiso paraneoplásico? Reporte de caso. Rev. Argent. Reumatol. [Internet]. 22 de septiembre de 2025 [citado 7 de octubre de 2025];36(2). Disponible en: https://ojs.reumatologia.org.ar/index.php/revistaSAR/article/view/963
Sección
Caso Clínico
