Fatiga en pacientes con espondiloartritis: datos en un centro de atención terciaria en Brasil
Palabras clave:
fatiga, espondiloartritis, actividad de la enfermedad
Resumen
Introducción: la fatiga es frecuente en los pacientes con espondiloartritis axial (SpA), afectando la calidad de vida y su causa no es completamente comprendida. Objetivos: estudiar factores asociados a fatiga en pacientes con SpA. Materiales y métodos: se incluyeron pacientes con SpA. La actividad de la enfermedad se constató mediante BASDAI (Bath Disease Activity Index), ASDAS-ESR (Ankylosing Spondylitis Disease Activity Score-eritrosedimentación) y ASDAS-CRP (proteína C reactiva). La depresión se midió por CES-D (Center for Epidemiological Scale–Depression), la función por BASFI (Bath Ankylosing Spondylitis Functional Index) y la calidad de vida por el SF-12. El FACIT (Functional Assessment of Chronic Illness Therapy-fatigue) se utilizó para medir la fatiga. Resultados: Se incluyeron 74 pacientes con SpA. La fatiga se correlacionó con BASDAI (rho=-0,74); BASFI (rho=-0,74); ASDAS-ESR (rho=-0,55); ASDAS-CRP (rho=-0,54); y CES-D (rho=-0,73). El modelo de regresión múltiple mostró que BASFI (coef β -2,60; 95%IC -3,65 a 1,55; p<0,0001) y CES-D (coef β -0,44; 95%IC 0,09 -0,63 a 0,24; p<0,0001) se correlacionaron con FACIT-fatiga, ajustado por ASDAS, artritis periférica, lesiones cutáneas, edad, sexo y años de la enfermedad. Conclusiones: En esta serie la fatiga en pacientes con SpA se asoció con la capacidad funcional y la depresión.Citas
I. Ali S, Matcham F, Irving K, Chalder T. Fatigue and psychosocial variables in autoimmune rheumatic disease and chronic fatigue syndrome: A cross-sectional comparison. J Psychosom Res. 2017; 92:1-8. doi: 10.1016/j.jpsychores.2016.11.002.
II. Mayoux-Benhamou MA. Fatigue and rheumatoid arthritis. Ann Readapt Med Phys. 2006; 49(6):301-4, 385-8. doi: 10.1016/j.annrmp.2006.04.011.
III. Katz P, Margaretten M, Trupin L, Schmajuk G, Yazdany J, Yelin E. Role of sleep disturbance, depression, obesity, and physical inactivity in fatigue in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2016; 68(1):81-90. doi: 10.1002/acr.22577.
IV. Nikolaus S, Bode C, Taal E, van de Laar MA. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken). 2013; 65(7):1128-46. doi: 10.1002/acr.21949.
V. Da Costa D, Dritsa M, Ring A, Fitzcharles MA. Mental health status and leisure-time physical activity contribute to fatigue intensity in patients with spondylarthropathy. Arthritis Rheum. 2004; 51(6):1004-8. doi: 10.1002/art.20841.
VI. Schneeberger EE, Marengo MF, Dal Pra F, Maldonado Cocco JA, Citera G. Fatigue assessment and its impact in the quality of life of patients with ankylosing spondylitis. Clin Rheumatol. 2015;34(3):497-501. doi: 10.1007/s10067-014-2682-3. doi: 10.1007/s10067-014-2682-3.
VII. Navarro-Compán V, Boel A, Boonen A, Mease P, Landewé R, Kiltz U, et al. The ASAS-OMERACT core domain set for axial spondyloarthritis. Semin Arthritis Rheum. 2021;51(6):1342-1349. doi: 10.1016/j.semarthrit.2021.07.021.
VIII. Bianchi WA, Elias FR, Carneiro S, Bortoluzzo AB, Gonçalves CR, da Silva JA, et al. Assessment of fatigue in a large series of 1492 Brazilian patients with Spondyloarthritis. Mod Rheumatol. 2014; 24(6):980-4. doi: 10.3109/14397595.2014.906049
IX. Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J et al. The development of assessment of Spondyloarthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009; 68:777-83. doi: 10.1136/ard.2009.108233.
X. Pimentel-Santos FM, Pinto T, Santos H, Barcelos A, Cunha I, Branco JC, et al. Portuguese version of the Bath indexes for ankylosing spondylitis patients: a cross-cultural adaptation and validation. Clin Rheumatol. 2012; 31:341-6. doi: 10.1007/s10067-011-1864-5.
XI. da Silveira DX, Jorge MR. Reliability and factor structure of the Brazilian version of the Center for Epidemiologic Studies-Depression. Psychol Rep. 2002; 91(3 Pt 1):865-74. doi: 10.2466/pr0.2002.91.3.865.
XII. Andrade TL, Camelier AA, Rosa FW, Santos MP, Jezler S, Pereira e Silva JL. Applicability of the 12-Item Short-Form Health Survey in patients with progressive systemic sclerosis. J Bras Pneumol. 2007; 33(4):414-22. doi: 10.1590/s1806-37132007000400010.
XIII. Ishikawa NM, Thuler LC, Giglio AG, Baldotto CS, de Andrade CJ, Derchain SF. Validation of the Portuguese version of functional assessment of cancer therapy-fatigue (FACT-F) in Brazilian cancer patients. Support Care Cancer. 2010 Apr;18(4):481-90. doi: 10.1007/s00520-009-0697-0.
XIV. Machado PM, Landewé R, Heijde DV. Assessment of SpondyloArthritis international Society (ASAS). Ankylosing Spondylitis Disease Activity Score (ASDAS): 2018 update of the nomenclature for disease activity states. Ann Rheum Dis. 2018; 77(10):1539-40. doi: 10.1136/annrheumdis-2018-213184
XV. Pereira da Costa I, Bortoluzzo AB, Gonçalves CR, Braga da Silva JA, Ximenes AC, Bértolo MB, et al. Evaluation of performance of BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) in a Brazilian cohort of 1,492 patients with spondyloarthritis: data from the Brazilian Registry of Spondyloarthritides (RBE). Rev Bras Reumatol. 2015 Jan-Feb;55(1):48-54. doi: 10.1016/j.rbr.2014.05.005.
XVI. Garcez Cusmanich K, Kowalski SC, Lopes Gallinaro A, Goldenstein-Schainberg C, Avila Lima E Souza L, Gonçalves CR. Cross-cultural adaptation and validation of the Brazilian-Portuguese version of the Bath Ankylosing Spondylitis Functional Index (BASFI). Rev Bras Reumatol. 2012 Oct;52(5):733-41.
XVII. Tavares Batistoni SS, Liberalesso Neri A, Bretas Cupertino APF. Validity of the Center for Epidemiological Studies Depression Scale among Brazilian elderly. Rev Saude Publica. 2007 Aug;41(4):598-605. doi: 10.1590/s0034-89102007000400014.
XVIII. Lucchetti G, Lamas Granero Lucchetti A, Piasseschi de Bernardin Gonçalves J, Vallada HP. Validation of the Portuguese version of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being scale (FACIT-Sp 12) among Brazilian psychiatric inpatients. J Relig Health. 2015 Feb;54(1):112-21. doi: 10.1007/s10943-013-9785-z.
XIX. Chauffier K, Paternotte S, Burki V, Durnez A, Elhaï M, Koumakis E, et al Fatigue in spondyloarthritis: a marker of disease activity. A cross-sectional study of 266 patients. Clin Exp Rheumatol. 2013; 31(6):864-70. PMID: 24144262
XX. Husted JA, Tom BD, Schentag CT, Farewell VT, Gladman DD: Occurrence and correlates of fatigue in psoriatic arthritis. Ann Rheum Dis. 2009; 68: 1553-8. doi: 10.1136/ard.2008.098202.
XXI. Calin A, Edmunds L, Kennedy LG: Fatigue in ankylosing spondylitis - why is it ignored? J Rheumatol. 1993; 20: 991-5. PMID: 8350337
XXII. Druce KL, Aikman L, Dilleen M, Burden A, Szczypa P, Basu N. Fatigue independently predicts different work disability dimensions in etanercept-treated rheumatoid arthritis and ankylosing spondylitis patients. Arthritis Res Ther. 2018; 20(1):96. doi: 10.1186/s13075-018-1598-8.
XXIII. Gossec L, Dougados M, D'Agostino MA, Fautrel B. Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort. Joint Bone Spine. 2016; 83(4):427-31. doi: 10.1016/j.jbspin.2015.07.012.
XXIV. Bedaiwi M, Sari I, Thavaneswaran A, Ayearst R, Haroon N, Inman RD. Fatigue in ankylosing spondylitis and nonradiographic axial spondyloarthritis: Analysis from a longitudinal observation cohort. J Rheumatol. 2015; 42(12):2354-60. doi: 10.3899/jrheum.150463.
XXV. Dagfinrud H, Vollestad NK, Loge JH, Kvien TK, Mengshoel AM. Fatigue in patients with ankylosing spondylitis: A comparison with the general population and associations with clinical and self-reported measures. Arthritis Rheum. 2005;53( 1):5-11. doi: 10.1002/art.20910.
XXVI. López-Medina C, Schiotis RE, Font-Ugalde P, Castro-Villegas MC, Calvo-Gutiérrez J, Ortega-Castro R, et al. Assessment of fatigue in spondyloarthritis and its association with disease activity. J Rheumatol. 2016; 43(4):751-7. PMID: 26879350
XXVII. Aissaoui N, Rostom S, Hakkou J, Berrada Ghziouel K, Bahiri R, Abouqal R, et al. Fatigue in patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status, and sleep disturbance. Rheumatol Int. 2012; 32(7):2117-24. doi: 10.1007/s00296-011-1928-5.
XXVIII. Günaydin R, Göksel Karatepe A, Ceşmeli N, Kaya T. Fatigue in patients with ankylosing spondylitis: relationships with disease-specific variables, depression, and sleep disturbance. Clin Rheumatol. 2009; 28(9):1045-51. doi: 10.1007/s10067-009-1204-1.
XXIX. Kumar A, Kumari B, Kumar P. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010; 26(1):17-27. doi: 10.1007/s12264-010-0713-x.
XXX. Maes M, Mihaylova I, Kubera M, Bosmans E. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett. 2007; 28(4):463-9. PMID: 17693978
XXXI. Dernis-Labous E, Messow M, Dougados M. Assessment of fatigue in the management of patients with ankylosing spondylitis. Rheumatology (Oxford). 2003; 42(12):1523-8. doi: 10.1093/rheumatology/keg421.
XXXII. Espahbodi S, Bassett P, Cavill C, Freeth M, Hole J, Sengupta R. Fatigue contributes to work productivity impairment in patients with axial spondyloarthritis: a cross-sectional UK study. Clin Exp Rheumatol. 2017; 35(4):571-8. PMID: 28240589
XXXIII. Connolly D, Fitzpatrick C, O'Shea F. Disease activity, occupational participation, and quality of life for individuals with and without severe fatigue in ankylosing spondylitis. Occup Ther Int. 2019; 2019:3027280. doi: 10.1155/2019/3027280.
II. Mayoux-Benhamou MA. Fatigue and rheumatoid arthritis. Ann Readapt Med Phys. 2006; 49(6):301-4, 385-8. doi: 10.1016/j.annrmp.2006.04.011.
III. Katz P, Margaretten M, Trupin L, Schmajuk G, Yazdany J, Yelin E. Role of sleep disturbance, depression, obesity, and physical inactivity in fatigue in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2016; 68(1):81-90. doi: 10.1002/acr.22577.
IV. Nikolaus S, Bode C, Taal E, van de Laar MA. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken). 2013; 65(7):1128-46. doi: 10.1002/acr.21949.
V. Da Costa D, Dritsa M, Ring A, Fitzcharles MA. Mental health status and leisure-time physical activity contribute to fatigue intensity in patients with spondylarthropathy. Arthritis Rheum. 2004; 51(6):1004-8. doi: 10.1002/art.20841.
VI. Schneeberger EE, Marengo MF, Dal Pra F, Maldonado Cocco JA, Citera G. Fatigue assessment and its impact in the quality of life of patients with ankylosing spondylitis. Clin Rheumatol. 2015;34(3):497-501. doi: 10.1007/s10067-014-2682-3. doi: 10.1007/s10067-014-2682-3.
VII. Navarro-Compán V, Boel A, Boonen A, Mease P, Landewé R, Kiltz U, et al. The ASAS-OMERACT core domain set for axial spondyloarthritis. Semin Arthritis Rheum. 2021;51(6):1342-1349. doi: 10.1016/j.semarthrit.2021.07.021.
VIII. Bianchi WA, Elias FR, Carneiro S, Bortoluzzo AB, Gonçalves CR, da Silva JA, et al. Assessment of fatigue in a large series of 1492 Brazilian patients with Spondyloarthritis. Mod Rheumatol. 2014; 24(6):980-4. doi: 10.3109/14397595.2014.906049
IX. Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J et al. The development of assessment of Spondyloarthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009; 68:777-83. doi: 10.1136/ard.2009.108233.
X. Pimentel-Santos FM, Pinto T, Santos H, Barcelos A, Cunha I, Branco JC, et al. Portuguese version of the Bath indexes for ankylosing spondylitis patients: a cross-cultural adaptation and validation. Clin Rheumatol. 2012; 31:341-6. doi: 10.1007/s10067-011-1864-5.
XI. da Silveira DX, Jorge MR. Reliability and factor structure of the Brazilian version of the Center for Epidemiologic Studies-Depression. Psychol Rep. 2002; 91(3 Pt 1):865-74. doi: 10.2466/pr0.2002.91.3.865.
XII. Andrade TL, Camelier AA, Rosa FW, Santos MP, Jezler S, Pereira e Silva JL. Applicability of the 12-Item Short-Form Health Survey in patients with progressive systemic sclerosis. J Bras Pneumol. 2007; 33(4):414-22. doi: 10.1590/s1806-37132007000400010.
XIII. Ishikawa NM, Thuler LC, Giglio AG, Baldotto CS, de Andrade CJ, Derchain SF. Validation of the Portuguese version of functional assessment of cancer therapy-fatigue (FACT-F) in Brazilian cancer patients. Support Care Cancer. 2010 Apr;18(4):481-90. doi: 10.1007/s00520-009-0697-0.
XIV. Machado PM, Landewé R, Heijde DV. Assessment of SpondyloArthritis international Society (ASAS). Ankylosing Spondylitis Disease Activity Score (ASDAS): 2018 update of the nomenclature for disease activity states. Ann Rheum Dis. 2018; 77(10):1539-40. doi: 10.1136/annrheumdis-2018-213184
XV. Pereira da Costa I, Bortoluzzo AB, Gonçalves CR, Braga da Silva JA, Ximenes AC, Bértolo MB, et al. Evaluation of performance of BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) in a Brazilian cohort of 1,492 patients with spondyloarthritis: data from the Brazilian Registry of Spondyloarthritides (RBE). Rev Bras Reumatol. 2015 Jan-Feb;55(1):48-54. doi: 10.1016/j.rbr.2014.05.005.
XVI. Garcez Cusmanich K, Kowalski SC, Lopes Gallinaro A, Goldenstein-Schainberg C, Avila Lima E Souza L, Gonçalves CR. Cross-cultural adaptation and validation of the Brazilian-Portuguese version of the Bath Ankylosing Spondylitis Functional Index (BASFI). Rev Bras Reumatol. 2012 Oct;52(5):733-41.
XVII. Tavares Batistoni SS, Liberalesso Neri A, Bretas Cupertino APF. Validity of the Center for Epidemiological Studies Depression Scale among Brazilian elderly. Rev Saude Publica. 2007 Aug;41(4):598-605. doi: 10.1590/s0034-89102007000400014.
XVIII. Lucchetti G, Lamas Granero Lucchetti A, Piasseschi de Bernardin Gonçalves J, Vallada HP. Validation of the Portuguese version of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being scale (FACIT-Sp 12) among Brazilian psychiatric inpatients. J Relig Health. 2015 Feb;54(1):112-21. doi: 10.1007/s10943-013-9785-z.
XIX. Chauffier K, Paternotte S, Burki V, Durnez A, Elhaï M, Koumakis E, et al Fatigue in spondyloarthritis: a marker of disease activity. A cross-sectional study of 266 patients. Clin Exp Rheumatol. 2013; 31(6):864-70. PMID: 24144262
XX. Husted JA, Tom BD, Schentag CT, Farewell VT, Gladman DD: Occurrence and correlates of fatigue in psoriatic arthritis. Ann Rheum Dis. 2009; 68: 1553-8. doi: 10.1136/ard.2008.098202.
XXI. Calin A, Edmunds L, Kennedy LG: Fatigue in ankylosing spondylitis - why is it ignored? J Rheumatol. 1993; 20: 991-5. PMID: 8350337
XXII. Druce KL, Aikman L, Dilleen M, Burden A, Szczypa P, Basu N. Fatigue independently predicts different work disability dimensions in etanercept-treated rheumatoid arthritis and ankylosing spondylitis patients. Arthritis Res Ther. 2018; 20(1):96. doi: 10.1186/s13075-018-1598-8.
XXIII. Gossec L, Dougados M, D'Agostino MA, Fautrel B. Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort. Joint Bone Spine. 2016; 83(4):427-31. doi: 10.1016/j.jbspin.2015.07.012.
XXIV. Bedaiwi M, Sari I, Thavaneswaran A, Ayearst R, Haroon N, Inman RD. Fatigue in ankylosing spondylitis and nonradiographic axial spondyloarthritis: Analysis from a longitudinal observation cohort. J Rheumatol. 2015; 42(12):2354-60. doi: 10.3899/jrheum.150463.
XXV. Dagfinrud H, Vollestad NK, Loge JH, Kvien TK, Mengshoel AM. Fatigue in patients with ankylosing spondylitis: A comparison with the general population and associations with clinical and self-reported measures. Arthritis Rheum. 2005;53( 1):5-11. doi: 10.1002/art.20910.
XXVI. López-Medina C, Schiotis RE, Font-Ugalde P, Castro-Villegas MC, Calvo-Gutiérrez J, Ortega-Castro R, et al. Assessment of fatigue in spondyloarthritis and its association with disease activity. J Rheumatol. 2016; 43(4):751-7. PMID: 26879350
XXVII. Aissaoui N, Rostom S, Hakkou J, Berrada Ghziouel K, Bahiri R, Abouqal R, et al. Fatigue in patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status, and sleep disturbance. Rheumatol Int. 2012; 32(7):2117-24. doi: 10.1007/s00296-011-1928-5.
XXVIII. Günaydin R, Göksel Karatepe A, Ceşmeli N, Kaya T. Fatigue in patients with ankylosing spondylitis: relationships with disease-specific variables, depression, and sleep disturbance. Clin Rheumatol. 2009; 28(9):1045-51. doi: 10.1007/s10067-009-1204-1.
XXIX. Kumar A, Kumari B, Kumar P. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010; 26(1):17-27. doi: 10.1007/s12264-010-0713-x.
XXX. Maes M, Mihaylova I, Kubera M, Bosmans E. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett. 2007; 28(4):463-9. PMID: 17693978
XXXI. Dernis-Labous E, Messow M, Dougados M. Assessment of fatigue in the management of patients with ankylosing spondylitis. Rheumatology (Oxford). 2003; 42(12):1523-8. doi: 10.1093/rheumatology/keg421.
XXXII. Espahbodi S, Bassett P, Cavill C, Freeth M, Hole J, Sengupta R. Fatigue contributes to work productivity impairment in patients with axial spondyloarthritis: a cross-sectional UK study. Clin Exp Rheumatol. 2017; 35(4):571-8. PMID: 28240589
XXXIII. Connolly D, Fitzpatrick C, O'Shea F. Disease activity, occupational participation, and quality of life for individuals with and without severe fatigue in ankylosing spondylitis. Occup Ther Int. 2019; 2019:3027280. doi: 10.1155/2019/3027280.
Publicado
2024-12-30
Cómo citar
1.
Skare TL, Weber Schiller M, Lipienski TS, Beckhauser AP, Simioni J, Nisihara R. Fatiga en pacientes con espondiloartritis: datos en un centro de atención terciaria en Brasil. Rev. Argent. Reumatol. [Internet]. 30 de diciembre de 2024 [citado 21 de febrero de 2025];35(4):102 -109. Disponible en: https://ojs.reumatologia.org.ar/index.php/revistaSAR/article/view/898
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Derechos de autor 2025 a nombre de los autores. Derechos de reproducción: Sociedad Argentina de Reumatología
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