CAPÍTULO 3: Consenso en temas de interés general relacionados con el tratamiento de la artritis reumatoidea

  • Emilce E. Schneeberger Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Argentina
  • Cecilia Asnal Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Alejandra Babini Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Guillermo Berbotto Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Tomás Cazenave Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Gustavo Citera Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • María de los Ángeles Correa Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • María Celina de la Vega Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Rodrigo García Salinas Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Carla Gobbi Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Hernán Maldonado Ficco Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Alejandro Martínez Muñoz Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Victoria Martiré Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Eduardo Mysler Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Silvia Papasidero Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Rodolfo Pérez Alamino Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Bernardo Pons-Estel Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Javier Rosa Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Darío Scublinsky Hospital Fernández, Ciudad Autónoma de Buenos Aires, Argentina
  • Anastasia Secco Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • José Velasco Zamora Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Luis Edson Velozo Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Paula Alba Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Natalia Zamora Hospital Interzonal General de Agudos "San José" de Pergamino, Provincia de Buenos Aires, Argentina
  • Carla Sol Maldini Instituto Modelo de Cardiología, Córdoba, Argentina
  • Laura Acosta Felquer Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Diana Fernández Ávila Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Facundo Vergara Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
  • Malena Viola Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave: Recomendaciones, Artritis reumatoidea, Sociedad Argentina de Reumatología

Resumen

En esta segunda parte de las recomendaciones, los expertos consideramos ciertos temas de interés general para incluir en la revisión sistemática de la literatura (RSL) y por sus características se analizaron de forma cualitativa (Tabla 1 y Material suplementario-Apéndice 4: capítulos 1-20).

Biografía del autor/a

Emilce E. Schneeberger, Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Rehabilitación Psicofísica
Cecilia Asnal, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Alejandra Babini, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Guillermo Berbotto, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Tomás Cazenave, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Gustavo Citera, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
María de los Ángeles Correa, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
María Celina de la Vega, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Presidente anterior de la Sociedad Argentina de Reumatología
Rodrigo García Salinas, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Carla Gobbi, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Hernán Maldonado Ficco, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Alejandro Martínez Muñoz, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Victoria Martiré, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Eduardo Mysler, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Silvia Papasidero, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Rodolfo Pérez Alamino, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Bernardo Pons-Estel, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Javier Rosa, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Darío Scublinsky, Hospital Fernández, Ciudad Autónoma de Buenos Aires, Argentina
MD, PhD, MSc, Prof., Universidad de Buenos Aires
Anastasia Secco, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
José Velasco Zamora, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Luis Edson Velozo, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Paula Alba, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Natalia Zamora, Hospital Interzonal General de Agudos "San José" de Pergamino, Provincia de Buenos Aires, Argentina
HIGA San José de Pergamino
Carla Sol Maldini, Instituto Modelo de Cardiología, Córdoba, Argentina
Instituto Modelo de Cardiología
Laura Acosta Felquer, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Diana Fernández Ávila, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Facundo Vergara, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)
Malena Viola, Sociedad Argentina de Reumatología (SAR), Ciudad Autónoma de Buenos Aires, Argentina
Sociedad Argentina de Reumatología (SAR)

Citas

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XXI. Sanmartí R, Tornero J, Narváez J, Muñoz A, Garmendia E, Ortiz AM, et al. Eficacia y seguridad de los glucocorticoides en la artritis reumatoidea: revisión sistemática de la literatura. Reumatol Clin. 2020;16(3):222-8.

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XXVII. Raza K, Saber TP, Kvien TK, Tak PP, Gerlag DM. Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials. Ann Rheum Dis. 2012;71(12):1921-3.

XXVIII. van Nies JAB, Tsonaka R, Gaujoux-Viala C, Fautrel B, van der Helm-van Mil AHM. Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts. Ann Rheum Dis. 2015;74(5):806-12.

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XXXV. Smolen JS, Landewé RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2023;82(1):3-18.

XXXVI. Abdelhafiz D, Baker T, Glascow DA, Abdelhafiz A. Biomarkers for the diagnosis and treatment of rheumatoid arthritis - a systematic review. Postgrad Med. 2023;135(3):214-23.

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LXII. Han J, Geng Y, Deng X, Zhang Z. Subclinical synovitis assessed by ultrasound predicts flare and progressive bone erosion in rheumatoid arthritis patients with clinical remission. A systematic review and metaanalysis. J Rheumatol. 2016;43(11):2010-8.

LXIII. Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, et al. Prediction of relapse after discontinuation of biologic agents by ultrasonographic assessment in patients with rheumatoid arthritis in clinical remission: high predictive values of total grayscale and power Doppler scores that represent residual synovial inflammation before discontinuation. Arthritis Care Res (Hoboken). 2014;66(10): 1576-81.

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LXXI. Gotzsche PC, Johansen HK. Short-term lowdose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis. Cochrane Database Syst Rev. 2004;2005(3):CD000189.

LXXII. Kirwan JR, Bijlsma JWJ, Boers M, SheaBJ. Effects of glucocorticoids on radiological progression in rheumatoid arthritis. Cochrane Database Syst Rev. 2007;2007(1):CD006356.

LXXIII. Ruyssen-Witrand A, Fautrel B, Saraux A, Le Loët X, Pham T. Cardiovascular risk induced by low-dose corticosteroids in rheumatoid arthritis: a systematic literature review. Joint Bone Spine. 2011;78(1):23-30.

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a randomized trial. Ann Intern Med. 2012;156(5):329-39.

LXXV. Palmowski A, Nielsen SM, Boyadzhieva Z, Schneider A, Pankow A, Hartman L, et al. Safety and efficacy associated with long-term low-dose glucocorticoids in rheumatoid arthritis: a systematic review and metaanalysis.Rheumatology (Oxford). 2023;62(8):2652-60.

LXXVI. Buttgereit F, da Silva JAP, Boers M, Burmester G-R, Cutolo M, Jacobs J, et al. Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis. 2002;61(8):718-22.

LXXVII. Capell HA, Madhok R, Hunter JA, Porter D, Morrison E, Larkinet J, et al. Lack of radiological and clinical benefit over two years of low dose prednisolone for rheumatoid arthritis: results of a randomised controlled trial. Ann Rheum Dis. 2004;63(7):797-803.

LXXVIII. Svensson B, Boonen A, Albertsson K, van der Heijde D, Keller C, Hafströmet I. Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. Arthritis Rheum. 2005;52(11):3360-70.

LXXIX. Boers M, Hartman L, Opris-Belinski D, Bos R, Kok MR, Da Silva J, et al. Estudio GLORIA (Glucocorticoid LOwdose in Rheumatoid Arthritis). Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial. Ann Rheum Dis. 2022;81(7):925-36.

LXXX. Wassenberg S, Rau R, Steinfeld P, Zeidler H. Very lowdose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 2005;52(11):3371-80.

LXXXI. Brance ML, Larroudé MS, Zamora NV, Bagur A, Graf CE, Giacoia E, et al. Argentine guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis in postmenopausal women and men aged 50 years and older. J Clin Rheumatol. 2023;29(5):e59-e70.

LXXXII. Glennon V, Whittle SL, Hill CL, Johnston RV, Avery JC, Grobler L, et al. Short-term glucocorticoids for flares in people with rheumatoid arthritis receiving diseasemodifying anti-rheumatic drugs (DMARDs) (Protocol). Cochrane Database Syst Rev. 2021:2021(11): CD014898.

LXXXIII. Bergstra S, Sepriano A, Kerschbaumer A, van der Heijde D, Caporali R, Edwards C, et al. Efficacy, duration of use and safety of glucocorticoids: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2023;82(1):81-94.

LXXXIV. Fraenkel L, Bathon J, England B, St Clair B, Arayssi T, Carandang K, et al. 2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2021;73(7):1108-23.

LXXXV. Martínez-López JA. Systematic review: is the use of NSAIDs safe during pregnancy in women with rheumatic disease? Reumatol Clin. 2008;4(5):191-6.

LXXXVI. Martínez-López JA, Loza E, Carmona L. Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding). Clin Exp Rheumatol. 2009;27(4):678-84.

LXXXVII. Burmester GR, Landewé R, Genovese MC, Friedman AW, Pfeifer ND, Varothai NA, et al. Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis. Ann Rheum Dis. 2017;76(2):414-7.

LXXXVIII. Mirdamadi K, Salinas T, Vali R, Papadimitropoulos M, Piquette-Miller M. Meta-analysis of pregnancy outcomes after exposure to TNF-α inhibitors during pregnancy for the treatment of arthritic diseases. J Popul Ther Clin Pharmacol. 2018;25(1):e53-e56.

LXXXIX. Tsao NW, Rebic N, Lynd LD, De Vera MA. Maternal and neonatal outcomes associated with biologic exposure before and during pregnancy in women with inflammatory systemic diseases: a systematic review and meta-analysis of observational studies. Rheumatology (Oxford). 2020;59(8):1808-17.

XC. Nguyen H, Ahmed K, Luo W, Flint J, Giles I. A Systematic review of the safety of non-TNF inhibitor biologic and targeted synthetic drugs in rheumatic disease in pregnancy. Semin Arthritis Rheum. 2021;51(6):1205-17.

XCI. Barenbrug L, Groen MT, Hoentjen F, van Drongelen J, van dern Reek JMPA, Joosten I, et al. Pregnancy and neonatal outcomes in women with immune mediated inflammatory diseases exposed to anti-tumor necrosis factor-α during pregnancy: A systemic review and meta-analysis. J Autoimmun. 2021;122: 102676.

XCII. Götestam Skorpen C, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016;75(5):795-810.

XCIII. Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, et al. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding. Part I: Standard and biologic disease modifying antirheumatic drugs and corticosteroids. Rheumatology (Oxford). 2016;55(9):1693-7.

XCIV. Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, et al. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding-Part II: Analgesics and other drugs used in rheumatology practice. Rheumatology (Oxford). 2016;55(9):1698-702.

XCV. Alhajeri H, Abutiban F, Al-Adsani W, Al-Awadhi A, Aldei A, AlEnizi A, et al. Kuwait association of rheumatology 2018 treatment recommendations for patients with rheumatoid arthritis. Rheumatol Int. 2019;39(9):1483-97.

XCVI. Sammaritano LR, Bermas BL, Chakravarty EE, Chambers C, Clowse MEB, Lockshin MD, et al. 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Arthritis Rheumatol. 2020;72(4):529-56.

XCVII. Mariette X, Förger F, Abraham B, Flynn AD, Moltó A, Flipo RM, et al. Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis. 2018;77(2):228-33.

XCVIII. Saavedra Salinas MÁ, Barrera Cruz A, Cabral Castañeda AR, Jara Quezada LJ, Arce-Salinas CA, Álvarez Nemegyei J, et al. Guías de práctica clínica para la atención del embarazo en mujeres con enfermedades reumáticas autoinmunes del Colegio Mexicano de Reumatología. Parte II. Reumatol Clin. 2015;11(5):305-15.

XCIX. Martínez-López JA, García-Vivar ML, Cáliz R, Freire M, Galindo M, Hernández MV, et al. Recomendaciones sobre actuaciones a seguir durante la edad fértil, el embarazo, posparto y lactancia en pacientes con enfermedades reumáticas inflamatorias y autoinmunes. Reumatol Clin. 2017;13(5):264-81.

C. Roodenrijs NMT, Hamar A, Kedves M, Nagy G, Van Laar JM, van der Heijde D, et al. Pharmacological and nonpharmacological therapeutic strategies in difficultto-treat rheumatoid arthritis. A systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis. RMD Open. 2021;7(1):e001512.

CI. Clowse ME, Förger F, Hwang C, Thorp J, Dolhain RJ, van Tubergen A, et al. Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis. 2017;76(11):1890-6.

CII. Levitsky A, Brismar K, Hafström I, Hambardzumyan K, Lourdudoss C, van Vollenhoven RF, et al. Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritis: results from the SWEFOT trial. RMD Open. 2017;3(2):e000458.

CIII. Villalba-Yllan A, Navarro-Compan V, PlasenciaRodríguez C, Peiteado-López D, Bonilla-Hernán G, Nuño-Nuño L, et al. Influence of body mass index (BMI) on the disease inflammatory activity and treatment reponse in patients with rheumatoid arthritis. Ann Rheum Dis. 2017;76(Suppl. 2):824.

CIV. Kaeley G, MacCarter D, Pangan A, Wang X, Kalabic J, Ranganath V. Clinical responses and synovial vascularity in obese rheumatoid arthritis patients treated with adalimumab and methotrexate. J Rheumatol. 2018;45(12):1628-35.

CV. Roodnrijs N, Hamar A, Kedves M, Nagy G, van Laar J, van der Heijde D, et al. Pharmacological and nonpharmacological therapeutic strategies in difficultto-treat rheumatoid arthritis: a systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis. RMD Open. 2021;7(1):e001512.

CVI. Nusslein H, Alten R, Galeazzi M, Lorenz H, Nurmohamed M, Benson, et al. Does body mass index impact longterm retention with abatacept in patients with RA who have received at least one prior biologic agent? 2-year results from a real-world, international, prospective study. Arthritis Rheumatol. 2014;66(S10):S1088-9.

CVII. Abuhelwa A, Hopkins A, Sorich M, Proudman S, Foster D, Wiese M. Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs. Sci Rep. 2020;10(1):18634.

CVIII. Yoo DH, Park W, Suh CH, Shim SC, Lee SJ, Bae YJ, et al. Rituximab is effective in the treatment of rheumatoid arthritis regardless of body mass index.Ann Rheum Dis. 2017;76(Suppl. 2):548.

CIX. Gialouri C, et al. Pappa M, Evangelatos G, Nikiphorou E, Fragoulis G. Effect of body mass index on treatment response of biologic/targeted-synthetic DMARDs in patients with rheumatoid arthritis, psoriatic arthritis or axial spondyloarthritis. A systematic review. Autoimmun Rev. 2023;22(7):103357.

CX. Shan J, Zhang J. Impact of obesity on the efficacy of different biologic agents in inflammatory diseases: A systematic review and meta-analysis. Joint Bone Spine. 2019;86(2):173-83.

CXI. Wasko MC, Kay J, Hsia EC, Rahman MU. Diabetes mellitus and insulin resistance in patients with rheumatoid arthritis: risk reduction in a chronic inflammatory disease. Arthritis Care Res (Hoboken). 2011;63(4):512-21.

CXII. Burska AN, Sakthiswary R, Sattar N. Effects of tumour necrosis factor antagonists on insulin sensitivity/ resistance in rheumatoid arthritis: A systematic review and meta-analysis. PLoS One. 2015;10(6):e0128889.

CXIII. Rempenault C, Combe B, Barnetche T, Gaujoux-Viala C, Lukas C, Morel J, et al. Metabolic and cardiovascular benefits of hydroxychloroquine in patients with rheumatoid arthritis: a systematic review and metaanalysis. Ann Rheum Dis. 2018;77(1):98-103.

CXIV. Baghdadi LR. Effect of methotrexate use on the development of type 2 diabetes in rheumatoid arthritis patients. A systematic review and meta-analysis. PLoS One. 2020;15(7):e0235637.

CXV. Lin C, Ji H, Cai X, Yang W, Lv F, Ji L. The association between the biological disease-modifying antirheumatic drugs and the incidence of diabetes: A systematic review and meta-analysis. Pharmacol Res. 2020;161:105216.

CXVI. Paul SK, Montvida O, Best JH, Gale S,Schramm AP, Sarsour K. Association of biological antirheumatic therapy with risk for type 2 diabetes: a retrospective cohort study in incident rheumatoid arthritis. BMJ Open. 2021;11(6):e042246.

CXVII. Ruscitti P, Masedu F, Alvaro S, Airò P, Battafarano N, Cantarini L, et al. Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial. PLoS Med. 2019;16(9):e1002901.

CXVIII. Desai RJ, Dejene S, Jin Y,Liu J, Kim SC. Comparative risk of diabetes mellitus in patients with rheumatoid arthritis treated with biologic or targeted synthetic disease-modifying drugs. A cohort study. ACR Open Rheumatol. 2020;2(4):222-31.

CXIX. Ursini F, Russo E, Hribal ML, Mauro D, Savarino F, Bruno C, et al. Abatacept improves whole-body insulin sensitivity in rheumatoid arthritis: an observational study. Medicine (Baltimore). 2015;94(21):e888.

CXX. van Lint JA, van Hunsel FPAM, Tas SW, Vonkeman HE, Hoentjen F, van Doorn MBA, et al. Hypoglycaemia following JAK inhibitor treatment in patients with diabetes. Ann Rheum Dis. 2022;81(4):597-9.

CXXI. Xie W, Yang X, Ji LL, Zhang Z. Incident diabetes associated with hydroxychloroquine, methotrexate, biologics and glucocorticoids in rheumatoid arthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. 2020;50(4):598-607.

CXXII. Ozen G, Pedro S, Holmqvist ME, Avery M, Wolfe F, Michaud K. Risk of diabetes mellitus associated with disease-modifying antirheumatic drugs and statins in rheumatoid arthritis. Ann Rheum Dis. 2017;76(5):848-54.

CXXIII. Mann DL, McMurray JJV, Packer M, Swedberg K, Borer JS, Colucci WS, et al. Targeted anticytokine therapy in patients with chronic heart failure. Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation. 2004;109(13):1594-602.

CXXIV. Setoguchi S, Schneeweiss S, Avorn J, Katz JN, Weinblatt ME, Levin R, et al. Tumor necrosis factor-α antagonist use and heart failure in elderly patients with rheumatoid arthritis. Am Heart J. 2008;156(2):33641.

CXXV. Heslinga SC, Van Sijl AM, De Boer K, Van Halm VP, Nurmohamed MT. Tumor necrosis factor blocking therapy and congestive heart failure in patients with inflammatory rheumatic disorders: a systematic review. Curr Med Chem. 2015;22(16):1892-902.

CXXVI. Barnabe C, Martin BJ, Ghali WA. Systematic review and meta-analysis: anti-tumor necrosis factor α therapy and cardiovascular events in rheumatoid arthritis. Arthritis Care Res. 2011;63(4):522-9.

CXXVII. Lee YH, Bae SC, Song GG. Hepatitis B virus (VHB) reactivation in rheumatic patients with hepatitis core antigen (VHB occult carriers) undergoing anti-tumor necrosis factor therapy. Clin Exp Rheumatol. 2013;31(1):118-21.

CXXVIII. Lee YH, Bae SC, Song GG. Hepatitis B virus reactivation in HBsAg-positive patients with rheumatic diseases undergoing anti-tumor necrosis factor therapy or DMARDs. Int J Rheum Dis. 2013;16(5):527-31.

CXXIX. Cantini F, Boccia S, Goletti D, Iannone F, Leoncini E, Panic N, et al. VHB reactivation in patients treated with antitumor necrosis factor-alpha (TNF-α) agents for rheumatic and dermatologic conditions: A systematic review and metaanalysis. Int J Rheumatol. 2014; 2014: 926836.

CXXX. van Vollenhoven R, Emery P, Bingham III C, Keystone E, Fleischmann R, Furst D, et al. Long-term safety of rituximab: pooled analysis of the rheumatoid arthritis global clinical trial programme over 11 years. Rheumatology 2014;53(Suppl 1):i97-i98.

CXXXI. Vassilopoulos D, Delicha EM, Settas L, Andrianakos A, Aslanidis S, Boura P, et al. Safety profile of repeated rituximab cycles in unselected rheumatoid arthritis patients: a long-term, prospective real-life study. Clin Exp Rheumatol. 2016;34(5):893-900.

CXXXII. Padovani M, Filipini M, Tincani A, Lanciono E, BruscheI E, Epis O, et al. Safety of abatacept in rheumatoid arthritis with serologic evidence of past or present hepatitis B virus infection. Arthritis Care Res. 2016;68(6):738-43.

CXXXIII. Ismajli M, Ionescu R, Moore S, Leandro M. Long-term use of rituximab in rheumatoid arthritis: 17 years followup. Rheumatology (Oxford). 2017;56(Suppl 2):ii142.

CXXXIV. Fukuda W, Hanyu T, Katayama M, Mizuki S, Okada A, Miyata M, et al. Incidence of hepatitis B virus reactivation in patients with resolved infection on immunosuppressive therapy for rheumatic disease: a multicentre, prospective, observational study in Japan. Ann Rheum Dis. 2017;76(6):1051-6.

CXXXV. Moghoofei M, Mostafaei S, Ashraf-Ganjouei A, Kavosi H, Mahmoudi M. VHB reactivation in rheumatic diseases patients under therapy: A meta-analysis. Microb Pathog. 2018;114:436-43.

CXXXVI. Chen YN, Huang WN, Wu YD, Lin CT, Chen YH, Chen DY, et al. Reactivation of hepatitis B virus infection in patients with rheumatoid arthritis receiving tofacitinib:

a real-world study. Ann Rheum Dis. 2018;77(5):780-2.

CXXXVII. Hsieh T-Y, Dickson C, Wu W-S, De La Torre I, Liao R, Winthrop K, et al. Hepatic safety in patients with rheumatoid arthritis treated with baricitinib: post-hoc analysis from clinical studies. Int J Rheum Dis. 2019;22(53):174-5.

CXXXVIII. Chen MH, Lee I-C, Chen MH, Hou MC, Tsai CY, Huang YH. Abatacept is second to rituximab at risk of HBsAg reverse seroconversion in patients with rheumatic disease. Ann Rheum Dis 2021;80(11):1393-9.

CXXXIX. Zhong Z, Liao W, Dai L, Feng X, Su G, Gao Y, et al. Average corticosteroid dose and risk for VHB reactivation and hepatitis flare in patients with resolved Hepatitis B infection. Ann Rheum Dis. 2022;81(4):584-91.

CXL. Hong X, Xiao Y, Xu L, Liu L, Mo H, Mo H. Risk of hepatitis B reactivation in HBsAg-/HBcAb+ patients after biologic or JAK inhibitor therapy for rheumatoid arthritis. A meta-analysis. Immun Inflamm Dis. 2023;11(2):e780.

CXLI. Fragoulis GE, Dey M, Zhao S, Schoones J, Courvoisier D, Galloway J, et al. Systematic literature review informing the 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases. RMD Open. 2022;8(2):e002726.

CXLII. Fragoulis GE, Nikiphorou E, Dey M, Zhao S, Courvoisier D, Laurent A, et al. 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2023;82(6):742-53.

CXLIII. Sebastiani M, Atzeni F, Milazzo L, Quartuccio L, Scirè C, Gaeta GB, et al. Italian consensus Guidelines for the management of hepatitis B virus infections in patients with rheumatoid arthritis. Joint Bone Spine. 2017;84(5):525-30.

CXLIV. Martín-Mola E, Hernández B, García-Arias M, ÁlvaroGracia JM, Balsa A, Reino JG, et al. Consenso de uso de rituximab en artritis reumatoidea. Un documento con recomendaciones basadas en la evidencia. Reumatol Clin. 2011;7(1):30-44.

CXLV. Nunes J, Marinho RT, Fonseca JE, Pereira da Silva JA, Velosa J. Prophylaxis of hepatitis B reactivation with immunosuppressive therapy in rheumatic diseases. Orientations for clinical practice. Acta Reumatol Port. 2011;36(2):110-8.

CXLVI. Maneiro JR, Souto A, Gomez-Reino JJ. Risks of malignancies related to tofacitinib and biological drugs in rheumatoid arthritis: Systematic review, metaanalysis, and network meta-analysis. Semin Arthritis Rheum. 2017;47(2):149-56.

CXLVII. Tank ND, Karelia B, Vegada B. Biological response modifiers in rheumatoid arthritis: systematic review and meta-analysis of safety. J Pharmacol Pharmacother. 2017;8(3):92-105.

CXLVIII. De La Forest Divonne M, Gottenberg JE, Salliot C. Safety of biologic DMARDs in RA patients in real life: a systematic literature review and meta-analyses of biologic registers. Joint Bone Spine. 2017;84(2):133-40.

CXLIX. Singh JA, Hossain A, Mudano AS, Tanjong Ghogomu E, Suarez‐Almazor ME, Buchbinder R, et al. Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network metaanalysis. Cochrane Database Syst Rev. 2017;5(5):CD012657.

CL. Huang F, Luo ZC. Risk of adverse drug events observed with baricitinib 2 mg versus baricitinib 4 mg once daily for the treatment of rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials. BioDrugs. 2018;32(5):415-23.

Publicado
2025-05-27
Cómo citar
1.
Schneeberger EE, Asnal C, Babini A, Berbotto G, Cazenave T, Citera G, Correa M de los Ángeles, de la Vega MC, García Salinas R, Gobbi C, Maldonado Ficco H, Martínez Muñoz A, Martiré V, Mysler E, Papasidero S, Pérez Alamino R, Pons-Estel B, Rosa J, Scublinsky D, Secco A, Velasco Zamora J, Edson Velozo L, Alba P, Zamora N, Maldini CS, Acosta Felquer L, Ávila DF, Vergara F, Viola M. CAPÍTULO 3: Consenso en temas de interés general relacionados con el tratamiento de la artritis reumatoidea. Rev. Argent. Reumatol. [Internet]. 27 de mayo de 2025 [citado 30 de mayo de 2025];36(Sup1):23 -7. Disponible en: https://ojs.reumatologia.org.ar/index.php/revistaSAR/article/view/932
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