CAPÍTULO 14: Recomendaciones argentinas para el manejo de pacientes adultos con espondiloartritis axial

  • María Victoria Martire Hospital San Roque de Gonnet, La Plata, Provincia de Buenos Aires, Argentina
  • Mariana Benegas Sanatorio Méndez, Ciudad Autónoma de Buenos Aires, Argentina
  • Carla Airoldi Hospital Provincial de Rosario, Rosario, Santa Fe, Argentina
  • Natalia Zamora HIGA San José de Pergamino, Provincia de Buenos Aires, Argentina
  • Enrique Soriano Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
  • Gustavo Citera Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina
  • Emilce Schneeberger Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave: espondiloartritis axial, recomendaciones

Resumen

La espondiloartritis axial (EspAax) es una enfermedad crónica inflamatoria que incluye a la espondiloartritis radiográfica (EspAax-r) (anteriormente conocida como espondilitis anquilosante [EA]) y a la espondiloartritis axial no radiográfica (EspAax-nr). Los pacientes con EspAax-nr pueden tener compromiso inflamatorio espinal detectado por resonancia magnética (RM) pero, a diferencia de los pacientes con EA, no tienen evidencia de daño estructural radiográfico suficiente para cumplir los criterios de New York modificados. Ambos fenotipos generan un importante impacto en la calidad de vida, el estado global de salud y la productividad laboral si no son tratados en forma oportuna y adecuada.

Biografía del autor/a

María Victoria Martire, Hospital San Roque de Gonnet, La Plata, Provincia de Buenos Aires, Argentina
Hospital San Roque de Gonnet
Mariana Benegas, Sanatorio Méndez, Ciudad Autónoma de Buenos Aires, Argentina
Sanatorio Méndez
Carla Airoldi, Hospital Provincial de Rosario, Rosario, Santa Fe, Argentina
Hospital Provincial de Rosario
Natalia Zamora, HIGA San José de Pergamino, Provincia de Buenos Aires, Argentina
HIGA San José de Pergamino
Enrique Soriano, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
Gustavo Citera, Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Rehabilitación Psicofísica (IREP)
Emilce Schneeberger, Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Rehabilitación Psicofísica (IREP)

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XCII. Deodhar A, Sliwinska-Stanczyk P, Xu H, Baraliakos X, Gensler LS, Fleishaker D, et al. Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study. Ann Rheum Dis. 2021;80(8):1004-1013.

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XCV. van der Heijde D, Baraliakos X, Gensler LS, Maksymowych WP, Tseluyko V, Nadashkevich O, et al. Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial. Lancet. 2018;392(10162):2378-2387.

XCVI. Giardina AR, Ferrante A, Ciccia F, Impastato R, Miceli MC, Principato A, et al. A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitis. Rheumatol Int. 2009;30(11):1437-1440.

XCVII. Wei JC, Tsou HK, Leong PY, Chen CY, Huang JX. Head-to-Head Comparison of etanercept vs. adalimumab in the treatment of ankylosing spondylitis. An open-label randomized controlled crossover clinical trial. Front Med (Lausanne). 2020;7:566160.

XCVIII. Ruwaard J, l'Ami MJ, Marsman AF, Kneepkens EL, van Denderen JC, van der Horst-Bruinsma IE, et al. Comparison of drug survival and clinical outcome in patients with ankylosing spondylitis treated with etanercept or adalimumab. Scand J Rheumatol. 2018;47(2):122-126.

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CII. Baji P, Péntek M, Szántó S, Géher P, Gulácsi L, Balogh O, et al. Comparative efficacy and safety of biosimilar infliximab and other biological treatments in ankylosing spondylitis: systematic literature review and meta-analysis. Eur J Health Econ. 2014 May;15 Suppl 1(Suppl 1):S45-52.

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CIV. Betts KA, Griffith J, Song Y, Mittal M, Joshi A, Wu EQ, et al. Network meta-analysis and cost per responder of tumor necrosis Factor-α and Interleukin inhibitors in the treatment of active ankylosing spondylitis. Rheumatol Ther. 2016;3(2):323-336.

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CVI. Wang R, Dasgupta A, Ward MM. Comparative efficacy of Tumor Necrosis Factor-α inhibitors in ankylosing spondylitis: a systematic review and bayesian network metaanalysis. J Rheumatol. 2018;45(4):481-490.

CVII. Ytterberg SR, Bhatt DL, Mikuls TR, Koch GG, Fleischmann R, Rivas JL, et al; ORAL Surveillance Investigators. Cardiovascular and cancer risk with tofacitinib in rheumatoid arthritis. N Engl J Med. 2022;386(4):316-326.

CVIII. Coates L, Packham JC, Creamer P, Hailwood S, Bhalla AS, Chakravarty K, et al. Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial. Clin Exp Rheumatol. 2017;35(3):445-451.

CIX. Li G, Lv CA, Tian L, Jin LJ, Zhao W. A retrospective study of alendronate for the treatment of ankylosing spondylitis. Medicine (Baltimore). 2018;97(20):e10738.

CX. Maksymowych WP, Jhangri GS, Fitzgerald AA, LeClercq S, Chiu P, Yan A, et al. A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis. Arthritis Rheum. 2002;46(3):766-773.

CXI. Mulleman D, Lauferon F, Wendling D, Ternant D, Ducourau E, Paintaud G, et al. Infliximab in ankylosing spondylitis: alone or in combination with methotrexate? A pharmacokinetic comparative study. Arthritis Res Ther. 2011;13(3):R82.

CXII. Li EK, Griffith JF, Lee VW, Wang YX, Li TK, Lee KK, et al. Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation. Rheumatology (Oxford). 2008;47(9):1358-1363.

CXIII. Nissen MJ, Ciurea A, Bernhard J, Tamborrini G, Mueller R, Weiss B, et al. The effect of comedication with a conventional synthetic disease-modifying antirheumatic drug on drug retention and clinical effectiveness of anti-tumor necrosis factor therapy in patients with axial spondyloarthritis. Arthritis Rheumatol. 2016;68(9):2141-2150.

CXIV. Breban M, Ravaud P, Claudepierre P, Baron G, Henry YD, Hudry C, et al. Maintenance of infliximab treatment in ankylosing spondylitis: results of a one-year randomized controlled trial comparing systematic versus on-demand treatment. Arthritis Rheum. 2008;58(1):88-97.

CXV. Pérez-Guijo VC, Cravo AR, Castro Mdel C, Font P, Muñoz-Gomariz E, Collantes-Estevez E. Increased efficacy of infliximab associated with methotrexate in ankylosing spondylitis. Joint Bone Spine. 2007;74(3):254-258.

CXVI. Nair AM, Sandhya P, Yadav B, Danda D. TNFα blockers followed by continuation of sulfasalazine and methotrexate combination: a retrospective study on cost saving options of treatment in Spondyloarthritis. Clin Rheumatol. 2017;36(10):2243-2251.

CXVII. Glintborg B, Ostergaard M, Krogh NS, Dreyer L, Kristensen HL, Hetland ML. Predictors of treatment response and drug continuation in 842 patients with ankylosing spondylitis treated with anti-tumour necrosis factor: results from 8 years' surveillance in the Danish nationwide DANBIO registry. Ann Rheum Dis. 2010;69(11):2002-2008.

CXVIII. Heiberg MS, Koldingsnes W, Mikkelsen K, Rodevand E, Kaufmann C, Mowinckel P, et al. The comparative one-year performance of anti- tumor necrosis factor alpha drugs in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: results from a longitudinal, observational, multicenter study. Arthritis Rheum. 2008;59(2):234-240.

CXIX. Kristensen LE, Karlsson JA, Englund M, Petersson IF, Saxne T, Geborek P. Presence of peripheral arthritis and male sex predicting continuation of anti-tumor necrosis factor therapy in ankylosing spondylitis: an observational prospective cohort study from the South Swedish Arthritis Treatment Group Register. Arthritis Care Res (Hoboken). 2010;62(10):1362-1369.

CXX. Favalli EG, Selmi C, Becciolini A, Biggioggero M, Ariani A, Santilli D, et al. Eight-Year Retention Rate of First-Line Tumor Necrosis Factor Inhibitors in Spondyloarthritis: A Multicenter Retrospective Analysis. Arthritis Care Res (Hoboken). 2017;69(6):867-874.

CXXI. Rahman P, Choquette D, Bensen WG, Khraishi M, Chow A, Zummer M, et al. Biologic Treatment Registry Across Canada (BioTRAC): a multicentre, prospective, observational study of patients treated with infliximab for ankylosing spondylitis. BMJ Open. 2016;6(4):e009661.

CXXII. Heinonen AV, Aaltonen KJ, Joensuu JT, Lahteenmaki JP, Pertovaara MI, Romu MK, et al. Effectiveness and drug survival of TNF inhibitors in the treatment of ankylosing spondylitis. A prospective cohort study. J Rheumatol. 2015;42(12):2339-2346.

CXXIII. Lie E, Kristensen LE, Forsblad-d'Elia H, Zverkova-Sandstrom T, Askling J, Jacobsson LT, et al. The effect of comedication with conventional synthetic disease modifying antirheumatic drugs on TNF inhibitor drug survival in patients with ankylosing spondylitis and undifferentiated spondyloarthritis: results from a nationwide prospective study. Ann Rheum Dis. 2015;74(6):970-978.

CXXIV. Sepriano A, Ramiro S, van der Heijde D, Avila-Ribeiro P, Fonseca R, Borges J, et al. Effect of comedication with conventional synthetic disease-modifying antirheumatic drugs on retention of tumor necrosis factor inhibitors in patients with spondyloarthritis. A prospective cohort study. Arthritis Rheumatol. 2016;68(11):2671-2679.

CXXV. Scire CA, Caporali R, Sarzi-Puttini P, Frediani B, Di Franco M, Tincani A, et al. Drug survival of the first course of anti-TNF agents in patients with rheumatoid arthritis and seronegative spondyloarthritis: analysis from the MonitorNet database. Clin Exp Rheumatol. 2013;31(6):857-863.

CXXVI. de Vries MK, Wolbink GJ, Stapel SO, de Vrieze H, van Denderen JC, Dijkmans BA, et al. Decreased clinical response to infliximab in ankylosing spondylitis is correlated with anti-infliximab formation. Ann Rheum Dis. 2007;66(9):1252-1254.

CXXVII. de Vries MK, van der Horst-Bruinsma IE, Nurmohamed MT, Aarden LA, Stapel SO, Peters MJ, et al. Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis. Ann Rheum Dis. 2009;68(4):531-535.

CXXVIII. de Vries MK, Wolbink GJ, Stapel SO, de Groot ER, Dijkmans BA, Aarden LA, et al. Inefficacy of infliximab in ankylosing spondylitis is correlated with antibody formation. Ann Rheum Dis. 2007;66(1):133-134.

CXXIX. Kneepkens EL, Wei JC, Nurmohamed MT, Yeo KJ, Chen CY, van der Horst-Bruinsma IE, et al. Immunogenicity, adalimumab levels and clinical response in ankylosing spondylitis patients during 24 weeks of follow-up. Ann Rheum Dis. 2015;74(2):396-401.

CXXX. Heinonen AV, Aaltonen KJ, Joensuu JT, Lähteenmäki JP, Pertovaara MI, Romu MK, et al. Effectiveness and drug survival of TNF inhibitors in the treatment of ankylosing spondylitis. A prospective cohort study. J Rheumatol. 2015;42(12):2339-2346.

CXXXI. Ducourau E, Rispens T, Samain M, Dernis E, Le Guilchard F, Andras L, et al. Methotrexate effect on immunogenicity and long-term maintenance of adalimumab in axial spondyloarthritis: a multicentric randomised trial. RMD Open. 2020 Jan;6(1):e001047.

CXXXII. Gulfe A, Kapetanovic MC, Kristensen LE. Efficacy and drug survival of anti-tumour necrosis factor-alpha therapies in patients with non-radiographic axial spondyloarthritis: an observational cohort study from Southern Sweden. Scand J Rheumatol. 2014;43(6):493-497.

CXXXIII. Chen J, Liu C. Sulfasalazine for ankylosing spondylitis. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004800.

CXXXIV. Micheroli R, Tellenbach C, Scherer A, Bürki K, Niederman K, Nissen MJ, et al. Effectiveness of secukinumab versus an alternative TNF inhibitor in patients with axial spondyloarthritis previously exposed to TNF inhibitors in the Swiss Clinical Quality Management cohort. Ann Rheum Dis 2020;79(9):1203-1209.

CXXXV. Gottenberg JE, Brocq O, Perdriger A, Lassoued S, Berthelot JM, Wendling D, et al. Non-TNF-targeted biologic vs a second anti-TNF drug to treat rheumatoid arthritis in patients with insufficient response to a first anti-TNF drug. A randomized clinical trial. JAMA. 2016;316(11):1172-1180.

CXXXVI. Song IH, Heldmann F, Rudwaleit M, Haibel H, Weiss A, Braun J, et al. Treatment of active ankylosing spondylitis with abatacept: an open-label, 24-week pilot study. Ann Rheum Dis. 2011;70(6):1108-1110.

CXXXVII. Lekpa FK, Farrenq V, Canouï-Poitrine F, Paul M, Chevalier X, Bruckert R, et al. Lack of efficacy of abatacept in axial spondylarthropathies refractory to tumor-necrosis-factor inhibition. Joint Bone Spine. 2012;79(1):47-50.

CXXXVIII. Deodhar A, Gensler LS, Sieper J, Clark M, Calderon C, Wang Y, et al. Three multicenter, randomized, double-blind, placebo-controlled studies evaluating the efficacy and safety of ustekinumab in axial spondyloarthritis. Arthritis Rheumatol. 2019;71(2):258-270.

CXXXIX. Poddubnyy D, Hermann KG, Callhoff J, Listing J, Sieper J. Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS). Ann Rheum Dis. 2014;73(5):817-823.

CXL. Song IH, Heldmann F, Rudwaleit M, Listing J, Appel H, Braun J, et al. Different response to rituximab in tumor necrosis factor blocker-naive patients with active ankylosing spondylitis and in patients in whom tumor necrosis factor blockers have failed: a twenty-four-week clinical trial. Arthritis Rheum. 2010;62(5):1290-1297.

CXLI. Baeten D, Østergaard M, Wei JC, Sieper J, Järvinen P, Tam LS, et al. Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of- concept, dose-finding phase 2 study. Ann Rheum Dis. 2018;77(9):1295-1302.

CXLII. Sieper J, Porter-Brown B, Thompson L, Harari O, Dougados M. Assessment of short-term symptomatic efficacy of tocilizumab in ankylosing spondylitis: results of randomised, placebo-controlled trials. Ann Rheum Dis. 2014;73(1):95-100.

CXLIII. Sieper J, Braun J, Kay J, Badalamenti S, Radin AR, Jiao L, et al. Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN). Ann Rheum Dis. 2015;74(6):1051-1057.

CXLIV. Taylor PC, van der Heijde D, Landewé R, McCue S, Cheng S, Boonen A. A phase III randomized study of apremilast, an oral phosphodiesterase 4 inhibitor, for active ankylosing spondylitis. J Rheumatol. 2021;48(8):1259-1267.

CXLV. Park W, Hrycaj P, Jeka S, Kovalenko V, Lysenko G, Miranda P, et al. A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study. Ann Rheum Dis. 2013;72(10):1605-1612.

CXLVI. Park W, Yoo DH, Jaworski J, Brzezicki J, Gnylorybov A, Kadinov V, et al. Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis: 54-week results from the randomized, parallel-group PLANETAS study. Arthritis Res Ther. 2016;18:25.

CXLVII. Xu H, Li Z, Wu J, Xing Q, Shi G, Li J, et al. IBI303, a biosimilar to adalimumab, for the treatment of patients with ankylosing spondylitis in China: a randomised, double-blind, phase 3 equivalence trial. Lancet Rheumatol. 2019;1(1):e35‐e43.

CXLVIII. Su J, Li M, He L, Zhao D, Wan W, Liu Y, et al. Comparison of the efficacy and safety of adalimumab (Humira) and the adalimumab biosimilar candidate (HS016) in Chinese patients with active ankylosing spondylitis. A multicenter, randomized, double-blind, parallel, phase III clinical trial. BioDrugs. 2020;34(3):381-393.

CXLIX. Lindström U, Glintborg B, Di Giuseppe D, Nordström D, Aarrestad Provan S, Gudbjornsson B, et al. Treatment retention of infliximab and etanercept originators versus their corresponding biosimilars: Nordic collaborative observational study of 2334 biologics naïve patients with spondyloarthritis. RMD Open. 2019;5(2):e001079.

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CLI. Yates M, Hamilton LE, Elender F, Dean L, Doll H, MacGregor AJ, et al. Is Etanercept 25 mg once weekly as effective as 50 mg at maintaining response in patients with ankylosing spondylitis? A randomized control trial. J Rheumatol. 2015;42(7):1177-1185.

CLII. Lian F, Zhou J, Wang Y, Chen D, Xu D, Liang L. Efficiency of dose reduction strategy of etanercept in patients with axial spondyloarthritis. Clin Exp Rheumatol. 2018;36(5):884-890.

CLIII. Lawson DO, Eraso M, Mbuagbaw L, Joanes M, Aves T, Leenus A, et al. Tumor necrosis factor inhibitor dose reduction for axial spondyloarthritis. A systematic review and meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken). 2021;73(6):861-872.

CLIV. Dhir V, Mishra D, Samanta J. Glucocorticoids in spondyloarthritis-systematic review and real-world analysis. Rheumatology (Oxford). 2021;60(10):4463-4475.

CLV. Mintz G, Enríquez RD, Mercado U, Robles EJ, Jiménez FJ, Gutiérrez G. Intravenous methylprednisolone pulse therapy in severe ankylosing spondylitis. Arthritis Rheum. 1981;24(5):734-736.

CLVI. Richter MB, Woo P, Panayi GS, Trull A, Unger A, Shepherd P. The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis. Clin Exp Immunol. 1983;53(1):51-59.

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CLIX. Peters ND, Ejstrup L. Intravenous methylprednisolone pulse therapy in ankylosing spondylitis. Scand J Rheumatol. 1992;21(3):134-138.

CLX. Malaviya AN, Kapoor S, Garg S, Ahmad I, Raja RR. A new strategy of drug treatment in NSAID-unresponsive ankylosing spondylitis: combination of pamidronate and methylprednisolone monthly intravenous infusions on the background of a combination of disease modifying drugs sulfasalazine and methotrexate. J Assoc Physicians India. 2007;55:193-197.

CLXI. Richter MB, Woo P, Panayi GS, Trull A, Unger A, Shepherd P. The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis. Clin Exp Immunol. 1983;53(1):51-9.

CLXII. Gaydukova IZ, Rebrov AP, Poddubnyy D. Efficacy and safety of intravenous methylprednisolone in the treatment of patients with active ankylosing spondylitis: Results of a 12-week, prospective, open-label, pilot (METALL) study. Ter Arkh. 2015;87(5):47-52.

CLXIII. Rihl M, Baerlecken N, Wiese B, Schmidt RE, Zeidler H. Intravenous glucocorticoid pulse therapy in active, NSAID refractory axial ankylosing spondylitis. A retrospective analysis spanning 12 months. J Arthritis. 2018;7:266. doi:10.4172/2167-7921.1000266.

CLXIV. Haibel H, Fendler C, Listing J, Callhoff J, Braun J, Sieper J. Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial. Ann Rheum Dis 2014;73(1):243-246.

CLXV. Mishra D, Dhir V, Naidu GSRSNK, Khullar A, Kumar V, Sharma S, et al. Efficacy of a step-down regimen of oral prednisolone in axial spondyloarthritis: result of a double-blind randomized controlled trial (COBRA-AS Study). Rheumatology (Oxford). 2021 Apr 6;60(4):1932-1941.

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CLXVII. Haroon M, Ahmad M, Baig MN, Mason O, Rice J, FitzGerald O. Inflammatory back pain in psoriatic arthritis is significantly more responsive to corticosteroids compared to back pain in ankylosing spondylitis: a prospective, open-labelled, controlled pilot study. Arthritis Res Ther. 2018;20(1):73.

CLXVIII. Maugars Y, Mathis C, Berthelot J-M, Charlier C, Prost A. Assessment of the efficacy of sacroiliac corticosteroid injections in spondylarthropathies: A double-blind study. Br J Rheumatol. 1996;35(8):767-770.

CLXIX. Luukkainen R, Nissila M, Asikainen E, Sanila M, Lehtinen K, Alanaatu A, et al. Periarticular corticosteroid treatment of the sacroiliac joint in patients with seronegative spondylarthropathy. Clin Exp Rheumatol. 1999;17(1):88-90.

CLXX. Günaydin I, Pereira PL, Fritz J, König C, Kötter I. Magnetic resonance imaging guided corticosteroid injection of sacroiliac joints in patients with spondylarthropathy. Are multiple injections more beneficial? Rheumatol Int. 2006;26(5):396-400.

CLXXI. Migliore A, Bizzi E, Massafra U, Vacca F, Martin-Martin LS, Granata M, et al. A new technical contribution for ultrasound-guided injections of sacroiliac joints. Eur Rev Med Pharmacol Sci. 2010;14(5):465-469.

CLXXII. Nam B, Kim TH, Lee SW, Kim H, Kim YJ, Jun JB, et al. Efficacy and safety of intra-articular sacroiliac glucocorticoid injections in ankylosing spondylitis. J Clin Rheumatol. 2022;28(1):e26-e32.

CLXXIII. Dhir V, Mishra D, Samanta J. Glucocorticoids in spondyloarthritis-systematic review and real-world analysis. Rheumatology (Oxford). 2021;60(10):4463-4475.

CLXXIV. Guignard S, Gossec L, Salliot C, Ruyssen-Witrand A, Luc M, Duclos M, et al. Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study. Ann Rheum Dis. 2006;65(12):1631-1634.

CLXXV. Braun J, Baraliakos X, Listing J, Sieper J. Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. Arthritis Rheum. 2005;52(8):2447-2451.

CLXXVI. Cobo-Ibáñez T, Del Carmen Ordóñez M, Muñoz-Fernández S, Madero-Prado R, Martín-Mola E. Do TNF-blockers reduce or induce uveitis? Rheumatology (Oxford). 2008 May;47(5):731-2.

CLXXVII. Fouache D, Goeb V, Massy-Guillemant N, Avenel G, Bacquet-Deschryver H, Kozyreff-Meurice M, et al. Paradoxical adverse events of anti-tumour necrosis factor therapy for spondyloarthropathies: a retrospective study. Rheumatology (Oxford) 2009;48(7):761-764.

CLXXVIII. Lee S, Park YJ, Lee JY. The effect of tumor necrosis factor-alpha inhibitors on uveitis in patients with ankylosing spondylitis. J Korean Med Sci. 2019;34(42):e278.

CLXXIX. Choi EY, Lee M, Lee CS. Uveitis occurrence in patients with ankylosing spondylitis according to the type of tumour necrosis factor inhibitor a cohort study of 175 patients. Clin Exp Rheumatol. 2020;38(6):1132-1137.

CLXXX. Lindström U, Bengtsson K, Olofsson T, Di Giuseppe D, Glintborg B, Forsblad-d'Elia H, et al. Anterior uveitis in patients with spondyloarthritis treated with secukinumab or tumour necrosis factor inhibitors in routine care: does the choice of biological therapy matter? Ann Rheum Dis. 2021;80(11):1445-1452.

CLXXXI. van der Horst-Bruinsma I, van Bentum R, Verbraak FD, Rath T, Rosenbaum JT, Misterska-Skora M, et al. The impact of certolizumab pegol treatment on the incidence of anterior uveitis flares in patients with axial spondyloarthritis: 48-week interim results from C-VIEW. RMD Open. 2020;6(1):e001161.

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CLXXXIV. Braun J, Baraliakos X, Listing J, Davis J, van der Heijde D, Haibel H, et al. Differences in the incidence of flares or new onset of inflammatory bowel diseases in patients with ankylosing spondylitis exposed to therapy with anti-tumor necrosis factor alpha agents. Arthritis Rheum. 2007;57(4):639-647.

CLXXXV. Sandborn WJ, Hanauer SB, Katz S, Safdi M, Wolf DG, Baerg RD, et al. Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2001;121(5):1088-1094.

CLXXXVI. Üsküdar Cansu D, Üsküdar Teke H, Temel T, Ertürk A, Kahraman O, Korkmaz C. Do anti-TNF agents increase the risk of inflammatory bowel disease evolution in patients with ankylosing spondylitis? Real life data. J Natl Med Assoc. 2019;111(3):262-269.

CLXXXVII. Korzenik J, Larsen MD, Nielsen J, Kjeldsen J, Nørgård BM. Increased risk of developing Crohn's disease or ulcerative colitis in 17 018 patients while under treatment with anti-TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease. Aliment Pharmacol Ther. 2019;50(3):289-294.

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Publicado
2024-07-01
Cómo citar
1.
Martire MV, Benegas M, Airoldi C, Zamora N, Soriano E, Citera G, Schneeberger E. CAPÍTULO 14: Recomendaciones argentinas para el manejo de pacientes adultos con espondiloartritis axial. Rev. Argent. Reumatol. [Internet]. 1 de julio de 2024 [citado 16 de octubre de 2024];35(Sup1):121 -146. Disponible en: https://ojs.reumatologia.org.ar/index.php/revistaSAR/article/view/840