Seguridad de la vacunación COVID-19 en una muestra de pacientes brasileños con lupus eritematoso sistémico

  • Bianca Lins Alencar Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
  • Valentina Busato Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
  • Renato Nisihara Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
  • Thelma Larocca Skare Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
Palabras clave: lupus eritematoso sistémico, COVID-19, vacunas, seguridad

Resumen

Objetivos: estudiar los efectos secundarios y el riesgo de exacerbación de la enfermedad después de la vacunación COVID-19 en una muestra de pacientes con lupus eritematoso sistémico (LES). Materiales y métodos: este estudio retrospectivo que investigó 101 pacientes con LES. Se determinó la actividad de la enfermedad mediante el Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) antes y después de dos dosis de vacuna contra SAR-COv-2. Se registraron los efectos secundarios después de la vacunación. Resultados: los pacientes que recibieron dos dosis de la misma vacuna fueron el 10,3% para CoronaVAc, el 42,2% para Pfizer y el 47,3% para AstraZeneca. Se detectaron efectos secundarios en el 76,2% y la mayoría fue leve/moderado. Los más frecuentes fueron: dolor local (62,3%), cefalea (36,6%) y fatiga (34,6%). El cambio en la mediana del SLEDAI antes de la primera dosis y después de la segunda no fue estadísticamente significativa (p=0,68). Solo el 4,1% de los individuos aumentó el SLEDAI ≥ de 3 puntos. Conclusiones: la vacunación contra la COVID-19 fue bien tolerada y segura en pacientes con LES.

Biografía del autor/a

Bianca Lins Alencar, Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
Escuela Evangélica de Medicina Mackenzie de Paraná
Valentina Busato, Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
Escuela Evangélica de Medicina Mackenzie de Paraná
Renato Nisihara, Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
Escuela Evangélica de Medicina Mackenzie de Paraná
Thelma Larocca Skare, Escuela Evangélica de Medicina Mackenzie de Paraná, Curitiba, Brasil
Escuela Evangélica de Medicina Mackenzie de Paraná

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Publicado
2024-03-26
Cómo citar
1.
Alencar BL, Busato V, Nisihara R, Larocca Skare T. Seguridad de la vacunación COVID-19 en una muestra de pacientes brasileños con lupus eritematoso sistémico. Rev. Argent. Reumatol. [Internet]. 26 de marzo de 2024 [citado 25 de junio de 2024];35(1):11 -6. Disponible en: https://ojs.reumatologia.org.ar/index.php/revistaSAR/article/view/791
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